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. 2021 Sep 17;12:680544. doi: 10.3389/fphys.2021.680544

Figure 4.

Figure 4

Lipoic acid supplementation alleviates iron accumulation caused by FA injection. Mice are treated as described in Figure 1. (A) Representative images of Perl’s staining. Arrows for iron accumulation. Bar=50μm. (B) Quantitative assessment of iron staining. (C) Iron content of kidney tissue. (D) Representative images of IHC staining for Ferritin (brown). (E) The expression of iron storage marker Ferritin, as determined by western blotting. (F) The expression of iron exporter marker ferroportin (FPN), as determined by western blotting. (G) Semi-quantitative assessments of Ferritin. (H) Semi-quantitative assessments of FPN. For the FA group vs. the control group, *indicates p<0.05, and **indicates p<0.01. For the LA-treated groups vs. the FA group, #indicates p<0.05, and ##indicates p<0.01.