Figure 7.

Lipoic acid supplementation decreases ferroptosis-mediated tubular cells death caused by FA injection. Mice are treated as described in Figure 1. (A) Representative images by TUNEL staining, showing the ferroptosis-mediated tubular cell death. White arrowheads for TUNEL-positive tubular cells (green) on kidney tissue sections; nuclei are labeled with DAPI (blue). Bar=50μm. (B) The number of TUNEL-positive nuclei per high-power field (Hpf). For the FA group vs. the control group, ^*indicates p<0.05, and ^**indicates p<0.01. For the LA-treated groups vs. the FA group, ^#indicates p<0.05, and ^##indicates p<0.01.