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. Author manuscript; available in PMC: 2022 Aug 7.
Published in final edited form as: Biomater Sci. 2021 Jun 7;9(15):5069–5091. doi: 10.1039/d1bm00423a

Table 1.

Linear PEGylated AMPs: decreasing PEG molecular weight increases both antimicrobial activity and mammalian cell toxicity

Year AMP Polymer Findings Ref.
2003 nisin A (3 kDa) PEG (5 kDa) Long PEG chain reduced AMP bactericidal activity and toxicity 44
2007 tachyplesin I (2.3 kDa) PEG (5 kDa) Long PEG chain reduced AMP bactericidal activity and toxicity 116
2007 magainin 2 (2.5 kDa) PEG (5 kDa) Long PEG chain reduced AMP bactericidal activity and toxicity 115
2008 MA (1.6 kDa) PEG (0.75 and 1.1 kDa) Decreasing PEG length improved bactericidal activity, but increased toxicity 118
2012 CaLL (2.8 kDa) PEG (0.67 and 1 kDa) Conjugation improved cytocompatibility; decreasing PEG length increased conjugate bactericidal activity 117
2014 poly(lysine-co-phenylalanine) (varied from 5.5 to 0.5 kDa) PEG (5 and 2 kDa) Decreasing PEG length improved conjugate bactericidal activity, but increased toxicity 57
2017 Peptide 77c (1.8 kDa) PEG (5 kDa) Conjugation to PEG reduced bactericidal activity 37
2020 cryptdin-2 (4.7 kDa) PEG (5 kDa) Conjugates retained bactericidal activity, reduced toxicity, and improved stability of AMP in murine serum 39