Figure 6.

Multivariable linear regression of CMV kinetics with polyfunctional CMV-specific T-cell immunity in letermovir recipients only. Multivariable linear regression examining association of viral kinetics in the first 100 days after HCT with polyfunctional CMV-specific T-cell responses at approximately day 90 after HCT among letermovir recipients only. Comparisons were adjusted for either peak CMV DNAemia (in log₁₀ scale as a continuous variable; A) or CMV shedding (percentage of positive CMV PCR tests collected per 10% increase; B). CMV-specific polyfunctionality was measured as absolute polyfunctional T-cell counts (as defined by the phenotype IFN-γ plus ≥1 functional marker; top half) or COMPASS PFSs (bottom half). Adjustments were also made for donor CMV serostatus, ALCs (≤300 vs >300 cells per mm³), and AUC of daily weight-based prednisone equivalent steroid dose in the first 100 days after HCT. CI, confidence interval; MD, mean difference.