Fig. 1. Design plan for radical fluoromethylation via halogen atom transfer (XAT) activation of fluoroiodomethane. (a) The fluoromethyl motif is prevalent in pharmaceutical compounds. (b) Existing methods for radical fluoromethylation require expensive radical precursors, and strong oxidants or reductants, and are limited in scope. (c) Proposed XAT activation of fluoroiodomethane. (d) This work: application of XAT activation of fluoroiodomethane towards radical monofluoromethylation of unsaturated C X bonds.
