Scheme 4. Substrate scope with in situ generated 1,3-dipoles.a aReaction conditions: (i) 4 (1.0 equiv.), 2a (1.1 equiv.), [Pd(π-C3H5)Cl]2 (5 mol%), L1 (15 mol%), CH2Cl2, rt, 24 h. Yield determined by 1H NMR integration against an internal standard (dimethyl sulfone or trans-stilbene oxide), isolated yield in parentheses. Enantiomeric ratio determined by chiral HPLC.
