Table 1.
| [CTA]/[I] | initiator | solvent | temp (°C) | time (h) | Mw (kDa) | PDI | yield (%) | drug% (wt) | |
|---|---|---|---|---|---|---|---|---|---|
| P-1 | 2.5 | V65 | DMSO/H+ | 50 | 24 | 51.8 | 1.10 | 35 | 7.2 |
| P-2 | 1.25 | V65 | DMSO/H+ | 50 | 24 | 66.3 | 1.17 | 39 | 6.6 |
| P-3 | 1.25 | VA044 | DMSO/H2O 3:1 (v/v) | 40 | 48 | 105 | 1.12 | 81 | 6.6 |
200 mg scale: 156 mg HPMA/44 mg MA-GFLG–PTX; PTX 3% molar ratio in feed.
Monomer concentration 16.6% (wt).
[M]/[CTA] = 1106.