Table 2.

Copolymerization of HPMA with MA-GFLG–GEM^a,b,c

	[CTA]/[I]	initiator	solvent	temp (°C)	time (h)	Mw (kDa)	PDI	yield (%)	drug% (wt)
G-1	2.5	V65	DMSO/H+	50	24	73.6	1.22	43	10.9
G-2	1.25	V65	DMSO/H+	50	24	97.6	1.20	65	11.4
G-3	2.5	VA044	DMSO/H2O 1:1 (v/v)	70	2	81.2	1.25	54	12.2
G-4	1.25	VA044	DMSO/H2O 3:1 (v/v)	40	48	148.3	1.27	76	12.6
G-5	1.25	VA044	DMSO/H2O 3:1 (v/v)	40	24	61.5	1.15	40	12.3

^a200 mg scale, 134 mg HPMA/66 mg MA-GFLG–GEM; GEM 9.1% molar ratio in feed.

^bMonomer concentration 16.6% (wt).

^c[M]/[CTA] = 1030.