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. Author manuscript; available in PMC: 2021 Oct 6.
Published in final edited form as: Mol Pharm. 2017 Feb 3;14(5):1384–1394. doi: 10.1021/acs.molpharmaceut.6b01005

Table 3.

Copolymerization of HPMA with MA-GFLG–PTX at Different Scalesa,b,c

feed ratio (mg)
no. scale (mg) HPMA MA-GFLG–PTX MA-Tyr [CTA]/[I] Mw (kDa) PDI yield (%) drug% (wt)
P-3 200 156 44 1.25 105 1.12 81 6.6
P-8 1200 857 327 16 1.5 90.9 1.09 63 6.1
P-16 1180 937.2 244.5 1.25 118.7 1.20 68.5 6.3
P-37 5000 4220 780 1.25 109.8 1.27 78 7.9
a

DMSO/H2O 3:1 (v/v) as solvent, monomer concentration 16.6% (wt).

b

VA-044 as initiator, 40 °C for 48 h.

c

[M]/[CTA] = 1040.