Table 6.

Pharmacokinetic Parameters for ¹²⁵I-Labeled Conjugates in Mice

	P–GEMa	2P–GEM	mP–GEM200	mP–GEM300
T1/2,α (h)	0.26 ± 0.02	1.09 ± 0.28	1.38 ± 0.40	1.74 ± 0.58
T1/2,β (h)	6.36 ± 0.66	34.53 ± 4.23	39.69 ± 4.00	33.94 ± 3.39
AUC (%ID h/mL blood)	108.7 ± 6.7	1189.0 ± 113.3	1290.2 ± 113.3	1251.3 ± 86.8
CL (mL/h)	0.92 ± 0.06	0.08 ± 0.008	0.07 ± 0.005	0.07 ± 0.005
MRT (h)	8.49 ± 0.88	48.74 ± 5.93	56.25 ± 5.58	47.93 ± 4.60
Vss (mL)	7.82 ± 0.38	4.09 ± 0.18	4.36 ± 0.18	3.83 ± 0.17

^aFrom ref 19.