Table 2.
Clinical characteristics of the safety population.
| Variable | Overall (N = 643) | Narcolepsy (n = 226) | OSA (n = 417) |
|---|---|---|---|
| Baseline FOSQ-10 total score,a mean (SD) | n = 518 | n = 185 | n = 333 |
| 13.1 (3.2) | 11.6 (3.0) | 13.9 (3.0) | |
| Baseline WPAI:SHP,a mean (SD) | |||
| % Work time missed (absenteeism) | n = 332 | n = 111 | n = 221 |
| 5.3 (11.8) | 9.8 (16.3) | 3.1 (7.9) | |
| % Impairment while working (presenteeism) | n = 326 | n = 108 | n = 218 |
| 43.5 (26.6) | 58.9 (21.1) | 35.9 (25.7) | |
| % Overall work impairment | n = 324 | n = 107 | n = 217 |
| 52.6 (26.5) | 67.5 (19.0) | 45.2 (26.5) | |
| % Activity impairment | n = 516 | n = 184 | n = 332 |
| 49.6 (26.8) | 64.1 (22.4) | 41.6 (25.7) | |
| Baseline SF-36v2,a mean (SD) | n = 519 | n = 186 | n = 333 |
| Physical component score | 46.2 (8.5) | 46.2 (8.7) | 46.1 (8.4) |
| Mental component score | 48.6 (9.2) | 45.4 (9.5) | 50.4 (8.5) |
| Role physical | 42.8 (10.6) | 39.5 (11.3) | 44.7 (9.6) |
| General health | 49.1 (9.3) | 48.7 (9.6) | 49.4 (9.2) |
| Vitality | 42.8 (9.5) | 39.7 (9.3) | 44.6 (9.2) |
| Physical functioning | 48.4 (8.1) | 49.4 (8.0) | 47.9 (8.1) |
| Bodily pain | 49.2 (9.7) | 50.3 (10.2) | 48.5 (9.3) |
| Role emotional | 48.8 (9.8) | 47.4 (10.4) | 49.5 (9.4) |
| Mental health | 51.2 (7.9) | 49.5 (8.7) | 52.1 (7.3) |
| Social functioning | 46.1 (10.4) | 41.6 (11.5) | 48.6 (8.9) |
aBaseline in the parent study. FOSQ-10 = Functional Outcomes of Sleep Questionnaire short version, OSA = obstructive sleep apnea, SD = standard deviation, SF-36v2 = Short Form Health Survey Version 2, WPAI:SHP = Work Productivity and Activity Impairment Questionnaire: Specific Health Problem.