Fig. 3. Dimerization-induced changes in the solvent and membrane PRE (based on Δ1H-Γ2,di-mono/1H-Γ2,mono values in Fig. S14b†) for each dimer state mapped onto the NMR-driven structure of the α–α (A) or α–β dimer (B) of KRAS–G12D on the membrane. Dimerization-induced changes in proximity to the membrane are represented by red (closer) and blue (further) arrows. The side chains of key residues for each dimerization interface are depicted. Switch I and II regions are colored red and yellow, respectively.
