Table 1.
Commercially and publicly available large natural product libraries
| Number of screening samples |
|||||
|---|---|---|---|---|---|
| Company/institute | aSample type (number) | Extracts (sample source #) | Fractions (extract source #) | Compounds (type) | Ref. |
|
| |||||
| Albany Molecular Research, Inc. (AMRI) | B/F and P (>190 000) | 102 000 (23 375) | 209 000 (12 349) | — | 205 |
| AnalytiCon Discovery | B/F (na); P (na); SS (>25 000) | — | — | >25 000 (SS); >5000 (NP) | 206 |
| bBioinformatics Institute Singapore (BII)—A*STAR Natural Product Library | B/F (>120 000); P (>37 000) | ∼270 000 (>157 000) | ∼70 000 (na) | 2600 (NP) | 207 |
| cDevelopmental Therapeutics Program—The National Cancer Institute | MI (>20 000); B/F (>25 000); P (>80 000) | >230 000 (>108 000) | 326 000 (46 570) | 419 (NP set IV)d | 26 |
| fFondazione Ricerca per la Vita (FIIRV) | B/F (>15 000) | 166 000 (15 000) | — | — | 208 |
| Fundación MEDINA | B/F (190 000) | >130 000 (na) | — | — | 209 |
| Griffith Institute for Drug Discovery (GRIDD)—Nature Bank | MI and P (30 000) | 10 000 (10 000) | 50 000 (10 000) | 210 | |
| InterBioScreen (IBS) | MI (na); B/F (na) and P (na) | — | — | >67 000 (NP) | 211 |
| Magellan BioScience Group, Inc. | MB (10 000); F (55 000) | >15 000 (na) | — | — | 212 |
| Mycosynthetix | F (>55 000) | 55 000 (na) | — | — | 213 |
| eNatural Products Discovery Institute (NPDI) | B/F (>30 000); P (>20 000) | 80 000 (na) | — | — | 214 |
| fPharmaMar | MI (>118 000); MB (>100 000) | 100 000 (na) | — | — | 215 |
| PhytoPharmacon | P (4000) | 4000 (4000) | 25 000 (4000) | 500 (NP) | 216 |
| RIKEN Natural Products Repository (NPDepo) | B/F (na) and P (na) | — | — | 8000 (NP) | 217 |
| The Institut de Chimie des Substances Naturelles (ICSN) | MI, B/F, and P (>7000) | 14 000 (7000) | — | — | 218 |
| The Natural Products Library Initiative at the Scripps Research Institute (Florida) | B (>5500) | 8500 (na) | 3400 (na) | 450 (NP) | 219 |
| The University of Mississippi—National Center for Natural Products Research | MI and F (>2000); P (>18 000) | >20 000 (>20 000) | >43 000 (>3400) | ∼700 (NP) | 220 |
| Unigen (PhytoLogix Library) | P (8000) | 9000 (na) | 200 000 (na) | — | 221 |
a
B = bacteria; F = fungi; MB = marine bacteria; MI = marine invertebrates; P = plant; NP = pure natural products; SS = semi-synthetic (NP-based); na = data not available.
b
Acquired from MerLion Pharmaceuticals (Singapore).
c
No cost for materials, recipients only cover shipping charges.
d
The current Natural Products Set IV was selected from the DTP Open Repository Collection of >4500 pure natural product compounds.
e
Former Merck and Schering-Plough Natural Product Libraries.
f
Accessed through InterLink Biotechnologies.222