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. 2021 Oct 1;35(19-20):1333–1338. doi: 10.1101/gad.348762.121

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© 2021 Shan et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — Transcriptomic changes in DPP4+ APCs following acute cold exposure. (A) Principal component analysis (PCA) of transcriptomic data obtained by bulk RNA-seq of DPP4+ PDGFRβ+ cells and DPP4− PDGFRβ+ cells isolated from iWAT of animals maintained at room temperature (22°C) or cold-exposed (CE; 6°C) for 1 day. n = 5 for each group. Each sample (n) represents cells pooled from two mice. (B) Volcano plot depicting the top 15 up-regulated and top 15 down-regulated genes in cold-exposed DPP4+ cells that encode predicted secreted proteins. See Supplemental Data Set S4.