Figure 3.
Comparing NS-Forest v1.3 and v2.0 marker gene sets. Heat maps of NS-Forest v1.3 (A) and v2.0 (B) markers from human middle temporal gyrus. The taxonomy along the top of each heat map is based upon the hierarchical clustering result described in Bakken et al. (2018) and Hodge et al. (2019). Expression values are log2 CPM cluster medians normalized by row. The colors correspond to the normalized median expression level for the marker gene (rows) for a given cell type cluster (columns), with high expression (greater than five) in red and low expression (zero to negative five) in blue/white. (C) A blowup of the cell type labels corresponding to the heat map columns in parts A and B. (D) Box plots of F-beta and Binary Scores produced by NS-Forest v1.3 and v2.0 for all 75 cell type marker gene combinations. (E) Correlation of F-beta and Binary Scores between NS-Forest v1.3 and v2.0.