Figure 4.

Overlapping peaks important for each topic with ChIP-seq peaks collected from cell type–specific TFs suggests at least some topics represent tissue types. Peaks associated with each topic were overlapped with ChIP-seq peaks for three cell type–specific TFs: HLH-1, which is specific for muscle (top); ELT-1, which is specific for seam cells (middle); and ELT-2, which is specific for the intestine (bottom). Topic distributions for peaks with ChIP-seq site overlaps were compared with the topic distribution for randomly sampled peaks, and the results are plotted here as the log₂ ratio of the overlap topic distribution to the random topic distribution. Error bars, 95% confidence interval for 100 random samples.