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. 2021 Oct;31(10):1952–1969. doi: 10.1101/gr.271791.120

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© 2021 Durham et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 9. — Subclustering of neurons reveals finer structure that distinguishes different types of neurons. (A) Cells with reads in peaks near genes with expression patterns specific to neuron subtypes cluster together (bbs-8: ciliated sensory neurons; gcy-32: oxygen sensory neurons; unc-30: GABA-ergic neurons; mec-7: touch receptor neurons; ceh-24: cholinergic neurons). (B) Cells in the UMAP plot are colored by the number of marker genes with nearby coaccessible peaks. Here, we show marker genes for the ASE neurons, a specific pair of ciliated sensory neurons, which are identified in one of the bbs-8 clusters from A (marked by the left-facing arrow), and show marker genes shared by the oxygen sensory neurons AQR, PQR, and URX, which further support the cluster marked with gcy-32 in A (marked by the right-facing arrow).