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. 2021 Sep 23;297(4):101218. doi: 10.1016/j.jbc.2021.101218

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The complete replication/transcription complex, with a stoichiometry of six nsp15, six nsp14, six nsp16, six nsp12, six nsp13, six nsp7, 12 nsp8, 12 nsp10, and 2 N proteins. The six nsp13 subunits are arranged across nsp12 pairs in 2/0 (A1/B1), 1/1 (A2/B2), and 0/2 (A3/B3) stoichiometries. The polymerase complexes with two associated nsp13 subunits (A1 and B3) bind the N protein with the TRS-L oligo and are responsible for template switching during negative-strand synthesis (transcription). The two polymerase complexes with a single nsp13 subunit (A2 and B2) are responsible for replication.