Table 1. Patient counts in de-identified data and the fraction of datasets excluded by our exclusion.

criteria. Dataset sizes are after the exclusion criteria are applied.

	Truven		UCM
Distinct patients	115,805,687		69,484
	Male	Female	Male	Female
ASD diagnosis count*	12,146	3018	307	70
Control count*	2,301,952	2,186,468	20,249	17,386
AUC at 125 weeks	82.3%	82.5%	83.1%	81.37%
AUC at 150 weeks	84.79%	85.26%	82.15%	83.39%
Excluded fraction of the datasets
Positive category	0.0002	0.0	0.0160	0.0
Control category	0.0045	0.0045	0.0413	0.0476
Average number of diagnostic codes in excluded patients (corresponding number in included patients)
Positive category	4.33 (35.93)	0.0 (36.07)	2.6 (9.75)	0.0 (10.18)
Control category	1.57 (17.06)	1.48 (15.96)	2.32 (6.8)	2.07 (6.79)

*Cohort sizes are smaller than the total number of distinct patients due to the following exclusion criteria: (i) At least one code within our complete set of tracked diagnostic codes is present in the patient record, and (ii) time lag between first and last available record for a patient is at least 15 weeks.