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. 2021 Oct 6;17(10):e1009386. doi: 10.1371/journal.pcbi.1009386

Fig 9. Simulated grey-box linear model output for the four pathways fitted individually to each of the 11 subjects’ fNIRS-tHb data during HD-tDCS (shaded grey).

Fig 9

The ensemble averaged fNIRS-tHb response across all subjects is shown with a dashed line. Plots (A1)–(A4) show the four pathways fitted to the HD-tDCS stimulated sensorimotor data, while the plots (B1)–(B4) show the four pathways fitted to the HD-tDCS non-targeted region of the contralateral sensorimotor cortex. Pathway 1: tDCS current density perturbing vessel (circumference) response through synaptic potassium pathway, Pathway 2: tDCS current density perturbing vessel (circumference) response through the astrocytic pathway, Pathway 3: tDCS current density perturbing vessel (circumference) response through perivascular potassium pathway, and Pathway 4: tDCS current density perturbing vessel (circumference) response through smooth muscle cells voltage-gated ion current channels pathway.