Table 2. State variables of the pathways for tDCS effects in the lumped model of the neurovascular unit for physiologically detailed modeling based on published literature [42,56,57,75].
| Compartments of the lumped model of the neurovascular unit | |||
|---|---|---|---|
| Synaptic Space | Intracellular Astrocyte Space | Perivascular Space | Arteriole smooth muscle cell (SMC) Intracellular Space |
| Potassium concentration in the synaptic space ([K+]S) | Astrocytic Inositol trisphosphate ([IP3]) | Perivascular potassium concentration, ([K+]P)
Perivascular calcium concentration ([Ca2+]P) |
Open KIR (Inward Rectifying Potassium) channel probability (k) |
| Astrocytic intracellular calcium concentration, ([Ca2+]A) | SMC Membrane Potential (VSMC) | ||
| Gating variable (h) | Open potassium channel probability (n) | ||
| TRPV4 (Transient Receptor Potential Vanniloid Related 4) channel open probability (ss) | Calcium concentration in the SMC ([Ca2+]SMC) | ||
| Calcium-dependent EET (Epoxyeicosatrienoic Acid) production in the cell ([EET]) | The fraction of attached cross-bridges (ω) | ||
| Open BK(Big Potassium) channel probability (nbk) | Normalized contractile component of length (yy) | ||
| Astrocyte Membrane Potential (Vk) | Mean circumference of the vessel (x) | ||