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. 2021 Sep 24;17(9):e1009941. doi: 10.1371/journal.ppat.1009941

Fig 1. Metabolic pathway regulation in MDR-TB.

Fig 1

(A) Unbiased pathway analysis using plasma HRM with C18 negative chromatography to compare the metabolome of persons with multidrug resistant (MDR)-TB (n = 85) to (A) asymptomatic controls without TB disease (n = 57) and (B) persons with drug susceptible (DS)-TB (n = 89) shows TCA cycle metabolism and multiple overlapping pathways in fatty acid synthesis, activation and metabolism were the most significantly regulated pathways in MDR-TB. The y-axis shows significantly regulated metabolic pathways and the x-axis shows the -log p-value for pathway enrichment adjusted for age, sex and HIV status. (C) Correlation analysis of primary metabolite adducts (M-H) mapping to significant pathways reveals a network of highly correlated metabolites involved in the TCA cycle, fatty acid metabolism and methionine and cysteine metabolism that were significantly increased in persons with MDR-TB.