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. 2021 Sep 24;17(9):e1009941. doi: 10.1371/journal.ppat.1009941

Fig 6. Proinflammatory immunometabolic changes are reversed with appropriate TB treatment.

Fig 6

In persons with multidrug resistant (MDR)-TB (n = 17) here was a significant decline in plasma concentrations of (A) succinate, (B) fumarate, (C) malate, and (D) arachidonic acid after 1 year of TB therapy with concentrations declining to similar levels as controls without Mtb infection. (E) While plasma itaconate concentrations increased after 2–4 months and 1 year of treatment, this did not meet statistical significance and remained significantly lower than controls. Plasma concentrations of (F) IL-1β, (G) IL-8, and (H) IL-4 also significantly declined after 1 year of treatment, but remained significantly higher than uninfected controls. (I) Plasma concentrations of GM-CSF did not significantly change with MDR-TB treatment and remained significantly lower than those of controls. Groups were compared using the Wilcox signed rank test: * p<0.05, ** p<0.01, *** p<0.001.