. 2021 Jun 28;18(8):2947–2958. doi: 10.1021/acs.molpharmaceut.1c00098

Table 2. Apparent Permeability (P_app) Evaluation of Commercial Valsartan and Here-Prepared Samples with HPMC (with and without Span 20) and Lactose Monohydrate (with and without Span 20) Using the Transwell Model with Caco-2 Cell Line.

formulation	P_appfor Caco-2 permeability (× 10^–6 cm/s)
VLS commercial	6.60 ± 1.86
VEH	6.69 ± 0.43
VEHS	22.26 ± 0.39
VEL	3.00 ± 0.03
VELS	5.12 ± 2.63
VEH-Mix	0.85 ± 0.21
VEHS-Mix	1.51 ± 0.83
VEL-Mix	0.37 ± 0.26
VELS-Mix	0.15 ± 0.04

Table 2. Apparent Permeability (Papp) Evaluation of Commercial Valsartan and Here-Prepared Samples with HPMC (with and without Span 20) and Lactose Monohydrate (with and without Span 20) Using the Transwell Model with Caco-2 Cell Line.