. 2021 Sep 1;10(10):1234–1242. doi: 10.1530/EC-21-0301
This work is licensed under a Table 1.
Baseline characteristics, admission values, and mortality within 30 and 90 days in patients hospitalized with COVID-19. Patients are grouped according to thyroid-stimulating hormone (TSH) concentrations.
| TSH ≥ 0.4 mIU/L (n = 103) | TSH < 0.4 mIU/L (n = 13) | Total (n = 116) | P-value | |
|---|---|---|---|---|
| Age, median (IQR) | 71 (58–80) | 75 (74–81) | 72 (59–80) | 0.31 |
| Sex (%) | ||||
| Females, n (%) | 66 (64) | 6 (46) | 72 (62) | 0.34 |
| BMI, median (IQR) | 28 (25–32) | 31 (28–35) | 29 (25–32) | 0.11 |
| BMI (%) | ||||
| <30 | 52 (50) | 5 (38) | 57 (49) | |
| ≥30 | 35 (34) | 6 (46) | 41 (35) | 0.56 |
| Serum TSH, median (IQR) | 1.15 (0.79–1.58) | 0.25 (0.21–0.31) | 1.04 (0.60–1.45) | 0.0004 |
| Serum TSH, n (%) | ||||
| Low (<0.4 mIU/L) | – | 13 (100) | 13 (11) | |
| Normal (0.4–4.80 mIU/L) | 102 (99) | – | 102 (88) | |
| High (>4.80 mIU/L) | 1 (1) | – | 1 (1) | 0.0004 |
| Free T4, median (IQR) pmol/L | 17 (15–18) | 19 (19–21) | 17 (15–18) | 0.0003 |
| Free T4, n (%) | ||||
| Low (<12 pmol/L) | 3 (3) | 0 (0) | 3 (3) | |
| Normal (12–22 pmol/L) | 95 (92) | 11 (85) | 106 (91) | |
| High (>22 mol/L) | 5 (5) | 2 (15) | 7 (6) | 0.26 |
| CRP, median (IQR) mg/L | 87 (49–151) | 98 (56–141) | 93 (50–150) | 0.86 |
| Blood lymphocyte count, median (IQR) 109/L | 1.02 (0.7–1.32) | 1.13 (0.75–1.28) | 1.02 (0.75–1.29) | 0.94 |
| Plasma LDH, median (IQR) U/L | 332 (244–430) | 434 (278–462) | 332 (250–455) | 0.38 |
| Respiratory rate at admission, median (IQR), b.p.m | 20 (18–26) | 24 (19–28) | 21 (18–28) | 0.33 |
| Peripheral oxygen saturation at admission, median (IQR), % | 95 (93–97) | 96 (91–98) | 95 (93–97) | 0.72 |
| Infiltrate on x-ray at admission (%) | 86 (83) | 12 (92) | 98 (84) | 0.67 |
| Days with symptoms before admission, median (IQR) | 7 (5–11) | 6 (6–10) | 7 (5–10) | 0.92 |
| Oxygen requirements at admission, n (%) | ||||
| No oxygen requirement | 21 (20%) | 1 (8%) | 22 (19%) | |
| Low flow oxygen requirement | 44 (43%) | 7 (54%) | 54 (44%) | |
| High flow oxygen requirement | 38 (37%) | 5 (38%) | 43 (37%) | |
| Mechanical ventilation | 0 | 0 | 0 | 0.52 |
| ICU admission during hospitalization, n (%) | 17 (17%) | 3 (23%) | 20 (17%) | 0.84 |
| Mechanical ventilation during hospitalization, n (%) | 16 (16%) | 3 (23%) | 19 (16%) | 0.77 |
| Hypertension, n (%) | 46 (45) | 7 (54) | 53 (46) | 0.74 |
| Diabetes, n (%) | 33 (32) | 5 (38) | 38 (33) | 0.88 |
| Astma, n (%) | 11 (11) | 1 (8) | 12 (10) | 1.00 |
| COPD, n (%) | 8 (8) | 1 (8) | 9 (8) | 1.00 |
| 30 days mortality, n (%) | 23 (22) | 5 (38) | 28 (24) | 0.35 |
| 90 days mortality, n (%) | 28 (27) | 6 (46) | 34 (29) | 0.27 |
COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; Free T4, free thyroxine; ICU, intensive care unit; IL-6, interleukin-6; IQR, inter-quartile range; LDH, lactate dehydrogenase; TSH, thyroid-stimulating hormone.
Bold indicates statistical significance.