. 2021 Aug 23;10(9):1189–1199. doi: 10.1530/EC-21-0404
This work is licensed under a Table 4.
Diagnostic accuracy of basal and post-synacthen cortisol (F) in 37 patients with central adrenal insufficiency (AI) and 137 adrenal sufficient patients. The threshold for AI was based on the ROC curve and Youden’s J index.
| Threshold level | SE, % (95% CI) | SP, % (95% CI) | LRneg, % (95% CI) | LRpos, % (95% CI) | AUC, % (95% CI) | |
|---|---|---|---|---|---|---|
| Serum F0 | 181 nmol/L | 86.1 (79.4–90.9) | 75.7 (59.8–86.6) | 0.18 (0.116–0.289) | 3.541 (1.998–6.276) | 0.9 (0.847–0.954) |
| Serum F30LDSST | 427 nmol/L | 78.8 (71.3–84.8) | 89.2 (75.3–95.7) | 0.237 (0.169–0.334) | 7.292 (2.878–18.473) | 0.921 (0.876–0.967) |
| ΔSerumF | 145 nmol/L | 73.7 (65.8–80.4) | 56.8 (40.9–71.3) | 0.463 (0.311–0.689) | 1.705 (1.163–2.499) | 0.691 (0.598–0.784) |
| Δ%SerumF | 114% | 64.9 (48.8–78.2) | 78.1 (70.5–84.2) | 0.45 (0.288–0.703) | 2.962 (1.995–4.398) | 0.704 (0.598–0.809) |
| Salivary F0 | 2.7 nmol/L | 83.2 (76.1–88.6) | 67.6 (51.5–80.4) | 0.248 (0.161–0.384) | 2.566 (1.602–4.11) | 0.837 (0.764–0.91) |
| Salivary F30LDSST | 12.1 nmol/L | 94.9 (89.8–97.5) | 83.8 (68.9–92.3) | 0.061 (0.029–0.127) | 5.852 (2.81–12.184) | 0.952 (0.917–0.987) |
| ΔSalivary_F | 7.5 nmol/L | 93.4 (87.9–96.5) | 78.4 (62.8–88.6) | 0.084 (0.044–0.161) | 4.321 (2.336–7.993) | 0.931 (0.887–0.974) |
| Δ%SalivaryF | 278% | 65.7 (57.4–73.1) | 73 (57–84.6) | 0.47 (0.347–0.637) | 2.431 (1.412–4.184) | 0.735 (0.641–0.830) |
| Salivary E0 | 18.4 nmol/L | 78.8 (71.2–84.8) | 82.9 (67.3–91.9) | 0.255 (0.179–0.365) | 4.599 (2.208–9.576) | 0.858 (0.78–0.935) |
| Salivary E30LDSST | 37.3 nmol/L | 87.6 (81–92.1) | 80 (64.1–90) | 0.155 (0.096–0.249) | 4.38 (2.251–8.521) | 0.91 (0.857–0.963) |
| ΔSalivary_E | 17.9 nmol/L | 80.3 (72.8–86.1) | 77.1 (61–87.9) | 0.255 (0.174–0.375) | 3.513 (1.901–6.493) | 0.854 (0.785–0.924) |
| Δ%SalivaryE | 207% | 20.2 (15.2–28.8) | 97.1 (85.5–99.5) | 0.812 (0.732–0.9) | 7.409 (1.405–52.524) | 0.615 (0.511–0.719) |
| Salivary F/E0 | 0.08 | 99.3 (95.9–99.9) | 8.6 (3–22.4) | 0.085 (0.009–0.794) | 1.086 (0.98–1.203) | 0.482 (0.363–0.601) |
| Salivary F/E30 | 0.33 | 79.6 (72.1–85.5) | 65.7 (49.1–79.2) | 0.311 (0.207–0.468) | 2.321 (1.456–3.7) | 0.774 (0.686–0.861) |
Δ, difference between peak and basal levels; Δ%, increase from basal to peak levels; AUC, area under the curve; E, cortisone; F/E, cortisol-to-cortisone ratio; LDSST, low-dose short synacthen test; LRneg, negative likelihood ratio; LRpos, positive likelihood ratio; SE, sensitivity; SP, specificity.