Table 3.

Inhibition constants and IC₅₀ values for inhibition of ADAMTS-7 by hydroxamates and TIMP-4.

Inhibitor	ATS7FP7		LTBP4S-A
	IC50	K i app	IC50
TIMP-4	18 ± 6.0	3.2 ± 1.0a	13b
JG23	710 ± 80	150 ± 20	590 ± 90
EDV33	330 ± 70	68 ± 14	112 ± 14

Values are reported in nanomolar. K_{i app} values were determined using the Cheng-Prusoff equation unless otherwise indicated. The data are presented as average ± SEM; n = 3.

^avalues determined at 5 nM ADAMTS-7 using Morrison equation.

^bvalues from Colige et al.⁸ using 10 nM ADAMTS-7.