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Selectivity profile of EDV33 against other metzincins using FRET peptides.
| ADAMTS-4 | ADAMTS-5 | MMP-2 | ADAMTS-7 | MMP-12 | ADAM-17 |
|---|---|---|---|---|---|
| 31 ± 1 | 6.5 ± 0.1 | 4.0 ± 0.3 | 68 ± 14 | 0.53 ± 0.06 | 4.3 ± 0.1 |
Ki app values are reported in nanomolar. The data are presented as average ± SEM; n = 3.
