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. 2021 Oct 6;10:e70408. doi: 10.7554/eLife.70408

Table 3. Parameters for release scheme models.

Model1 Model2 Model3
k on 2.95*109 Ca2+(t) M−1 s−1 k on,init 5.10*108 Ca2+(t) M−1 s−1 k on1 0.5 kon2
k on,plug 0.1 kon,init k on2 5.10*108 Ca2+(t) M−1 s−1
k off 4.42*105 s−1 k off,init 2.55*104 s−1 k off1 10 koff2
k off,plug 0.4 koff,init k off2 2.55*104 s−1
b 0.25 b 0.25 b 0.25
γ 1.77*104 s−1 γ 1.77*104 s−1 γ 1.77*104 s−1
k prim 0.6+30*(Ca2+(t)/(KD,prim +Ca2+(t))) s−1 k prim1 2.5+60*(Ca2+(t)/(KD,prim1 +Ca2+(t))) s−1 k prim1 30 s−1
k unprim 0.6+30*(Ca2+Rest/(KD,prim + Ca2+Rest)) s−1 k unprim1 2.5+60*(Ca2+Rest/(KD,prim1 + Ca2+Rest)) s−1 k unprim1 30 s−1
K D,prim 2 µM K D,prim1 2 µM
k prim2 100+800*(Ca2+(t)/(KD,prim2 +Ca2+(t))) s−1 k prim2 0.5+30*(Ca2+(t)/(KD,prim2 +Ca2+(t))) s−1
k unprim2 100+800*(Ca2+Rest/(KD,prim2 + Ca2+Rest)) s−1 k unprim2 0.5+30*(Ca2+Rest/(KD,prim2 + Ca2+Rest)) s−1
K D,prim2 2 µM K D,prim2 2 µM