Table 2. Genotypes and AMR profiles for 153 sequenced S. Typhi isolates.
Percentages indicate genotype frequencies amongst cases or controls (first two columns); or frequency of antimicrobial resistance determinants amongst isolates of a given genotype (remaining columns). MDR, multi-drug resistant; L1, lineage I; L2, lineage II.
| Genotype | Cases | Controls | MDR | GyrA mutation | GyrB mutation | |||
|---|---|---|---|---|---|---|---|---|
| Plasmid | Chromosome | S83F | S83Y | D87G | S464F | |||
| All | 99 | 54 | 83 | 33 | 3 | 17 | 2 | 75 |
| 2.2.2 | 0 | 1 (1.9%) | 0 | 0 | 0 | 0 | 0 | 0 |
| 2.5.0 | 1 (1.0%) | 2 (3.7%) | 0 | 0 | 0 | 0 | 0 | 0 |
| 3.0.0 | 2 (2.0%) | 1 (1.9%) | 0 | 0 | 0 | 0 | 0 | 0 |
| 4.1.1 | 0 | 1 (1.9%) | 0 | 0 | 0 | 0 | 0 | 0 |
| 4.3.1 (H58) | 96 (97%) | 49 (91%) | 83 (57%) | 33 (23%) | 4(2.8%) | 19(13%) | 2(1.4%) | 75(51.7%) |
| H58 subgroups | ||||||||
| EA1 (L1) | 35 (35%) | 20 (37%) | 29 (53%) | 17 (31%) | 4(7.3%) | 2(3.6%) | 2(3.6%) | 2(3.6%) |
| EA2 (L2) | 46 (46%) | 27 (50%) | 54 (74%) | 0 | 0 | 0 | 0 | 73(100%) |
| EA3 (L2) | 15 (15%) | 2 (3.7%) | 0 | 16 (94%) | 0 | 17(100%) | 0 | 0 |