Table 2. Agreements between the washout, 6-sampling time point, and the no-washout, single-clinic visit 2 time-point PK protocols for the PK parameters of clearance and terminal half-life generated using the ADVATE myPKFiT dosing tool and factor VIII:C levels ^a .

	PK parameter	One-stage assay	Chromogenic assay
		ICC (95% CI)	ICC (95% CI)
All participants ( n  = 35)	Cl (mL/h/kg)	0.73 (0.52, 0.85)	0.54 (0.25, 0.74)
	t1/2 (h)	0.84 (0.70, 0.91)	0.80 (0.63, 0.89)
O blood group ( n  = 12)	Cl (mL/h/kg)	0.52 (−0.04, 0.84)	0.35 (−0.25, 0.76)
	t1/2 (h)	0.37 (−0.23, 0.76)	0.37 (−0.23, 0.77)
Non-O blood group ( n  = 20)	Cl (mL/h/kg)	0.83 (0.63, 0.93)	0.50 (0.08, 0.76)
	t1/2 (h)	0.93 (0.84, 0.97)	0.85 (0.66, 0.94)

Abbreviations: Cl, clearance; PK, pharmacokinetic; t _1/2 , terminal half-life.

Note: Data for 35/39 subjects were available for analysis: the ADVATE myPKFiT application was unable to generate PK parameters for the 2-point PKs of four subjects (two subjects had doses <10 IU/kg which is outside the allowable range of 10–100 IU/kg for the dosing tool, one subject had technical issues with the FVIII:C samples and one subject did not have adequate documentation of the FVIII infusion prior to the clinic visit for the 2-sampling time point PK study). Blood group status was not available for three subjects.

^aFactor VIII:C determinations done in central laboratory.