Table 5 Surgical axillary interventions and NACT.
| Oxford | ||||||||
|---|---|---|---|---|---|---|---|---|
| LoE | GR | AGO | ||||||
| * Participation in AXSANA trial recommended; ** only radiotherapy for ypN1 (sn), ypN+ not recommended; ***recommendation grade is referred to staging for cN0 and cN+ ypN0. | ||||||||
| SLNE after NACT SLNE before NACT |
2b 2b |
B B |
++ – |
|||||
| cN status (before NACT) | pN status (before NACT) | cN status (after NACT) | Surgical axillary intervention (after NACT) | pN status (after NACT and surgery) | Surgical consequences of histological findings | |||
| cN0 | – | ycN0 | SLNE alone | ypN0 (sn) | – | 2b | B | ++*** |
| ypN0 (i+) ypN1 mic (sn) |
ALND | 2b | C | + (+/– with i+) | ||||
| none** | 5 | D | +/− | |||||
| ypN1 (sn) | ALND | 2b | C | ++ | ||||
| none** | 5 | D | +/− | |||||
| cN+ | pN+ CNB | ycN0 | SLNE alone* TAD (TLNE + SLNE)* ALND* |
ypN0 ypN0 ypN0 |
– | 2b 2b 2b |
B B B |
+/−*** +*** +*** |
| SLNE alone* TAD (TLNE + SLNE)* |
ypN+ incl. ypN0 (i+) | ALND | 2b | B | + (+/– with i+) | |||
| ALND | ypN+ | – | 2b | B | ++ | |||
| none | n. d. | none** | 5 | D | – | |||
| cN+ | pN+ CNB | ycN+ | ALND | ypN+ incl. ypN0 (i+) | – | 2b | B | ++ |
| None | n. d. | none** | 5 | D | – | |||