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. 2021 Jul 6;81(10):1128–1144. doi: 10.1055/a-1475-4335

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Abb. 1 — Zelluläre Komponenten des Immunmilieus im Ovarialkarzinom und ausgewählte wichtige Interaktionsmechanismen. CD8-positive zytotoxische T-Zellen und natürliche Killerzellen sind entscheidende Mediatoren der Anti-Tumor-Antwort im Ovarialkarzinom. Sie werden auf unterschiedliche Arten durch dendritische Zellen, CD4-positive T-Helferzellen und M1-Makrophagen unterstützt. Demgegenüber führen M2-Makrophagen sowie MDSCs, z. B. durch Ausschüttung von IL-10 und TGF-β, zu einer Immunsuppression und einer Aktivierung regulatorischer T-Zellen, die ihrerseits die Funktion der anderen, tumorsuppressiven T-Zellen hemmen können. Einzelheiten sowie weitere Mechanismen im Haupttext.