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. 2021 Sep 29;2021:5147069. doi: 10.1155/2021/5147069

Figure 3.

Figure 3

Effects of sesamin on I/R-induced histological alteration in rat intestine. (a) Representative images of pathological changes of intestinal mucosal tissues (H&E staining, original magnification ×200). (A) Sham operation group; (B) SE(H)+sham operation group; (C) I/R group: a large number of intestinal villi epithelial cells fall off in the mucosal layer (black arrow), more intestinal villi become blunt, the mucosal layer is slightly edema, connective tissue is loosely arranged, the distance between intestinal glands is widened (blue arrow), and a small number of lymphocytes are scattered (red arrow); a small amount of lymphocyte infiltration can be seen in the submucosa and serosal layer (yellow arrow); (D) SE(L)+I/R group and (E) SE(H)+I/R group: after sesamin pretreatment, the intestinal mucosal damage has been significantly improved with the increase of the dose and the inflammatory cells and bleeding are reduced. (b) Chiu's score for the damage of the intestinal mucosa (n = 3). (c) Serum ALT (n = 5) and (d) serum AST (n = 5). All data were expressed as mean ± SEM. ∗∗∗P < 0.001vs. the sham-operation group; #P < 0.05, ##P < 0.01, and ###P < 0.01vs. the I/R group.