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. 2021 Oct 6;598(7879):214–219. doi: 10.1038/s41586-021-03220-z

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, UMAP visualizations showing expression of canonical marker genes of cerebellar interneuron development (Tfap2b, Ascl1, Neurog1, Neurog2 and Pax2), and of mature PLIs (Klhl1). b, Allen Developing Mouse Brain Atlas expression staining of Tfap2b across four developmental time points, showing that MLI progenitors begin to enter the molecular layer around P14. c, Interneuron developmental trajectory coloured by annotated clusters. d, Heat map showing the loading of Monocle3-defined gene modules across undifferentiated interneuron precursors, MLI1 and MLI2. Cells are ordered in each block by pseudotime rank. e, UMAP visualizations showing expression of selected top-loading genes from the indicated Monocle3-defined modules. f, Dot plot showing the transient, MLI2-specific expression of three activity-regulated genes (Fos, Junb and Fosl2) and two genes whose expression persists in adulthood (Fam135b and Sorcs2).