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. 2021 Oct 6;598(7879):214–219. doi: 10.1038/s41586-021-03220-z

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, c, e, g, UMAP representation of the integrative analyses of UBC (1,613 mouse; 3,893 human) (a), MLI/PLI (45,555 mouse; 14,971 human) (c), Golgi (3,989 mouse; 1,059 human) (e), and granule (119,972 mouse; 130,335 human) (g) cells, coloured by species (top), or joint cluster (bottom, for MLI and PLI, Golgi, and granule only). b, d, f, Heat maps showing expression of selected genes in UBC (b), MLI and PLI (d), and Golgi (f). Profiles are segregated both by species and cluster. UBC profiles are ordered by iNMF factor loadings for factor corresponding to OFF UBCs. h, Left, dot plot showing expression of selected genes in granule clusters, within human (red) and mouse (blue). Right, proportional representation of lobule dissections across the granule clusters. Granule cluster numbers approximately correspond to the mouse-only clusters shown in Fig. 2e.