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. 2021 Oct 6;598(7879):129–136. doi: 10.1038/s41586-021-03604-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 16 — a, Distribution plot of the Jensen–Shannon specificity scores of the differentially accessible cCREs and invariable cCREs. The vertical line shows the cutoff at FDR of 0.05. b, Stacked bar charts showing the number of differential cCREs between cell types for subclasses. c, A graph shows the numbers of differential cCREs in each major brain region. d, A graph shows the numbers of differential cCREs across subregions. The sizes of dots correspond to the number of differential cCREs (log₁₀-transformed) found in each cell type between brain regions, and the colours of the dots indicate the major brain regions in c, subregions in d.