Extended Data Fig. 11. GPe projection maps.

The majority of striatal domains project to GPe with restricted terminal fields that have little overlap and convergence among one another. This largely parallelized striatopallidal topography is evident at the domain-, community-, and level-scale resolution in the reconstruction maps. a, Domain-level projection maps of all striatopallidal terminations, colored according to their striatal source domain. Collectively, the entire CP sends projections that cover the entire GPe. Projections from individual CP domains follow a rostral to rostral and caudal to caudal pattern (i.e., rostral CP to rostral GPe, etc.), a topography similar to the primate striatopallidal pathway³⁸. No projections from any individual CP domain span the entire rostrocaudal extent of the pallidum. b, Community-level view of striatopallidal terminations depicts axons of all CP domains colored to match their parent community (e.g., reconstructions of axons from CPi.dl.d and CPi.dl.imd are colored blue for community CPi.dl), revealing that the dorsoventral and mediolateral topography of the CP is generally maintained in the GPe. c, Axonal reconstructions originating from all striatal domains of rostral, intermediate, and caudal CP levels are colored red, green, or blue, respectively. The rostral-to-rostral and caudal-to-caudal striatopallidal topography is easily apparent in these maps. The CPext projects to the most caudal levels of GPe (not shown here). d, The somatotopic map in the GPe is revealed by striatopallidal terminations from body region-specific striatal source domains: trunk (tr), lower limb (ll), upper limb (ul), inner mouth (m/i), and outer mouth (m/o). The raw source images are shown in the photomicrographs (coronal plane, medial is left, scalebar = 200µm) and the axonal reconstructions in the co-registered connectivity map. Axons were pseudocolored to match their striatal source domain. These images were used in the striatofugal analysis.