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. 2021 Oct 6;598(7879):120–128. doi: 10.1038/s41586-020-03182-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, b, The proportion of subtype (a) or shuffled DMRs (b) in each block of specific effect size and number of DMSs. c, The empirical FDR of each block, calculated by (no. of shuffle-DMRs/no. of subtype-DMRs) in each block. DMRs with effect size <0.3 were excluded in further analyses. d, The odds ratio of transcription factor motif enrichment in single-DMS DMRs (sDMRs) and multi-DMS DMRs (mDMRs). Each dot represents a transcription factor. Transcription factors whose motifs are significantly enriched in both sDMRs and mDMRs are coloured in green, and transcription factors that are significant only in sDMR or mDMRs are coloured in red or blue, respectively. Non-significant transcription factors are shown in grey.