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. 2021 Oct 6;598(7879):120–128. doi: 10.1038/s41586-020-03182-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b, Level 2 UMAP of excitatory (a) and inhibitory (b) neurons, coloured by subtype, dissection region and global mCH fraction. c, d, Integration UMAP of the HIP excitatory neurons profiled by snmC-seq2 (c) and snATAC-seq (d; shows pseudo-cells). e, Overlap score of a-types and m-types. f, Overlap of CG-DMR and ATAC peaks in matched subtypes. g, i, j, Integration t-SNE of ET-L5 neurons profiled by snmC-seq2 (g) and epi-retro-seq (i, j), coloured by dissection region. Three SSp- and MOp-enriched subtypes are labelled by their marker gene. j, Medulla projecting neurons from SSp or MOp only. h, Spatial composition of ET-L5 subtypes.