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. 2021 Oct 6;598(7879):174–181. doi: 10.1038/s41586-021-03941-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Example single-neuron morphologies for each of the 11 projection neuron types. Numbers in parentheses denote the number of neurons shown in each indicated region. In this and all subsequent figures, neurons are flipped to the left hemisphere for comparison of axon projection patterns. Left, CCFv3 3D brain models with anatomical delineation of all cortical and selected subcortical regions (striatum (STR), TH, superior colliculus (SC), PG, MY and cerebellum (CB)). b, Summary of the projection neuron types and their morphological and projectional features. Hyphens denote features not investigated in this study. Our transcriptomic study (H.Z. et al., unpublished results) suggests that most of these thalamocortical projection neurons are in the Prkcd_Grin2c transcriptomic subclass, whereas those from nucleus of reuniens (RE) and paraventricular nucleus (PVT) are not. ACA, anterior singulate area; AI, agranular insular area; AM, anteromedial nucleus; AUD, auditory areas; CM, central medial nucleus; GU, gustatory area; IAD, interanterodorsal nucleus; LD, lateral dorsal nucleus; RSP, retrosplenial area; SMT, submedial nucleus; VIS, visual area; VISC, visceral area; VM, ventral medial nucleus; VPMpc, ventral posteromedial nucleus, parvicellular part.