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. 2021 Oct 6;598(7879):174–181. doi: 10.1038/s41586-021-03941-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Clustering of Car3 neurons from all regions based on four feature sets: projection pattern, soma location, axon morphology and dendrite morphology. The dashed line indicates the threshold for cluster calls. Only clusters with a minimum of three cells are shown; thus, three cortical cells are omitted. Each cluster is annotated by the main brain regions where somas (black) and axon terminals (red) reside. Regions are selected to represent more than 50% of cluster members. Bi-ipsi, bilateral or ipsilateral. b, Projection matrix with cells sorted by cluster assignment. Columns represent single cells. Rows represent targets, and the number following each target name indicates the dominant cluster ID for the row. Heat map colours represent projection strengths, defined as ln(axon length). We identified four CTX L6 Car3 cells from ECT and several CLA neurons with axon collaterals projecting into amygdala areas, consistent with previous studies^32,46. c, Total number of cortical targets innervated by each neuron grouped by clusters. Two different thresholds are used to label a region as targeted. With a threshold of at least one terminal bouton, we find an average of 18 targets for CLA and 11 for CTX Car3 neurons. Using a minimum of 1 mm of axon length results in 21 and 14 targets for CLA and CTX Car3 neurons, respectively. Cell numbers are shown in d. Whiskers show outliers below minima or above maxima. d, Whole-brain top-down view of neurons in each cluster (all cells are shown for each cluster, with cell number in parentheses). ACAd, anterior cingulate area, dorsal part; ACAv, anterior cingulate area, ventral part; ENT, entorhinal area; ENTm, entorhinal area, medial part; LA, lateral amygdalar nucleus; MO, motor cortex; ORB, orbital area; ORBvl, orbital area, ventrolateral part; PAR, parasubiculum; POST, postsubiculum; RSPv, retrosplenial area, ventral part; SS, somatosensory cortex; SUB, subiculum.