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. 2021 Oct 6;598(7879):159–166. doi: 10.1038/s41586-021-03970-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Related to Fig. 1. Panels show retrogradely labeled neurons in secondary motor (MOs), primary motor (MOp), and primary somatosensory (SSp) cortical regions following injections of AAVretro-GFP (green) in cervical spinal cord and AAVretro-Cre (red) in lumbar spinal cord in an Ai14-tdTomato Cre-reporter mouse. Values indicate position of coronal sections relative to bregma. Prominent projections to cervical spinal cord arise from anterior MOs (also known as the rostral forelimb area) and more caudally from MOp between +0.7 to +0.1 mm from bregma (also known as the caudal forelimb area). This latter population serves to define the rostro-caudal extent of MOp upper limb domain (MOp-ul), the focus of this study. The lateral aspect of this labeling extends into primary somatosensory area upper limb domain (SSp-ul) and continues caudally to −1.5 mm posterior to bregma. Upper limb-related somatic sensorimotor areas transition into hindlimb- (MOp-ll and SSp-ll) and trunk- (MOp-tr and SSp-tr) related areas caudal to Bregma −0.1 mm, indicated by the increased presence of lumbar-projecting neurons (red). Injection sites in the contralateral cervical and lumbar spinal cord are shown in the bottom right panels. Scale bars, 500 µm.