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. 2021 Oct 6;598(7879):159–166. doi: 10.1038/s41586-021-03970-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 17 — a, Examples of reconstructed cells within MOp cortical layers 2/3/4 (orange) and 5 (blue) (see Methods). Note some L4-5 Cux2/Etv1 neurons lack an apical branch. The total neurons reconstructed for each mouse strain are: MORF3 (@UCLA/USC) x Cux2-CreERT2 (n=9) or Etv1-CreERT2 (n=36); TIGRE-MORF (@AIBS) x Cux2-CreERT2 (n=16), Fezf2-CreERT2 (n=3), or Pvalb-Cre (n=4). b, Principal component analysis (PCA) shows segregation of MOp layer-specific neurons based on measured morphological features. c, Wilcoxon Signed-Rank tests were run (all parameters survived the false discovery rate correction) and group differences between layers 2/3/4 and 5 basal dendritic trees of UCLA/USC (L2-4 [n=11], L5 [n=34]) and AIBS (L2-4 [n=16], L5 [n=7]) cases separately are presented in whisker plots and the degree of their significance is indicated by stars. d, Sholl-like analysis comparing basal dendritic patterns in MOp layer 5 and layers 2/3/4 neurons. The distribution of normalized dendritic length is plotted against the relative path distance from the soma. The graph shows that dendrites of neurons within layer 5 of MOp have slightly larger dendritic length closer to the cell body compared to the dendrites of layers 2/3/4 neurons. e, Persistence-based neuronal feature vectorization was also applied to summarize pairwise differences between superficial and deep neurons for UCLA/USC and AIBS datasets independently. For whisker plots in c and e, the center line represents the median, box limits show the upper and lower quartiles and the whiskers represent the minimum and maximum values.