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. 2021 Oct 6;598(7879):200–204. doi: 10.1038/s41586-021-03910-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Left, schematic showing the anatomical brain regions sampled for this study. The timeline below highlights the number of individuals sampled at each gestational week. Right, matrix showing the final count (after quality control) of cells from each individual distributed across regions sampled. b, Single cells from all brain regions sampled are represented in UMAP space. Cells are colour-coded by their region of origin. Insets show the expression profile of canonical genes representative of each identity. c, Top left, distribution of cell types and states in UMAP space. Constellation plot of cells grouped by type or state and brain region highlights the interplay between cell type (node colour) and regional identity (node label). Nodes are scaled proportionally to the number of cells in each group. Edge thickness at each end represents the fraction of cells within a group with neighbours in the opposite group. Node colour corresponds to cell type or state; node label corresponds to the brain region from which cells were sampled. ACx, allocortex; CB, cerebellum; CL, claustrum; GE, ganglionic eminences; HT, hypothalamus; M, motor cortex; MB, midbrain; NCx, neocortex; Par, parietal cortex; PCx, proneocortex; S, somatosensory cortex; Str, striatum; T, temporal lobe; Th, thalamus.