Extended Data Fig. 3. Correspondence between the MOp consensus RNA-seq cell-type taxonomy and previously published VISp/ALM cell-type taxonomy³.

a, Cells from all scRNA and snRNA MOp datasets were mapped to the most correlated VISp/ALM cell types based on VISp/ALM cell-type markers. The size of the dots indicates the number of overlapping cells, and the colour indicates the Jaccard index (number of cells in intersection/number of cells in union). MOp L5 ET types are mapped predominantly to L5 pyramidal tract (PT) ALM types in the VISp/ALM study. Note that we have adopted the nomenclature ‘extratelencephalically projecting (ET)’ for these neurons, instead of the previously used ‘pyramidal tract (PT)’, owing to the fact that not all of these neurons project to the pyramidal tract leading to the spinal cord. b, Three L5 PT ALM types can be divided into two groups with distinct projection patterns. Cells in the pink group project to the medulla and have been functionally associated with movement initiation, while the cells in the green group project to the thalamus, associated with movement planning. Adapted from Economo et al. (2018)¹⁸. c, Enlarged view of the correspondence between MOp L5 ET types and VISp/ALM L5 PT types. Two subsets of medulla-projecting (pink) and thalamus-projecting (green) L5 PT cells are highlighted.