Table 2.
Treatment effects on urinary renin-angiotensin, endothelin-1, and protein excretions
| Measurement | Treatment | Baseline | 2 weeks | 4 weeks |
|---|---|---|---|---|
| Urine renin, ng/mmol Cr | NaHCO3 | 0.7, 0.4–2.2 | 0.9, 0.3–3.3 | 0.9, 0.2–3.1 |
| NaCl | 1.1, 0.3–3.7 | 1.1, 0.1–4.3 | 1.2, 0.2–5.4 | |
| Time control | 1.4, 0.5–2.8 | 1.6, 0.5–2.4 | 1.8, 0.3–3.1 | |
| Urine aldosterone, ng/mmol Cr | NaHCO3 | 337, 171–1179 | 318, 125–513 | 356, 166–426 |
| NaCl | 335, 142–787 | 337, 126–627† | 317, 156–779 | |
| Time control | 353, 216–501 | 394, 142–676 | 293, 181–750 | |
| Urine angiotensinogen, µg/mmol Cr | NaHCO3 | 2.0, 0.4–83.5 | 4.3, 0.4–84.7 | 4.3, 0.2–104.5 |
| NaCl | 7.1, 0.5–22.9 | 7.7, 0.4–30.9* | 6.2, 0.4–39.0* | |
| Time control | 2.0, 0.8–61.5 | 2.9, 0.9–55.3 | 5.5, 0.8–78.5 | |
| Urine endothelin-1, ng/mmol Cr | NaHCO3 | 0.02, 0.01–0.56 | 0.05, 0.01–0.31 | 0.02, 0.01–0.29 |
| NaCl | 0.02, 0.01–0.07 | 0.02, 0.01–0.07 | 0.02, 0.01–0.07 | |
| Time control | 0.02, 0.01–0.06 | 0.02, 0.01–0.04 | 0.02, 0.01–0.05 | |
| Urine albumin, mg/mmol Cr | NaHCO3 | 30.4, 3.7–208.3 | 36.7, 5.8–196.9 | 40.4, 5.1–189.6 |
| NaCl | 38.7, 1.6–124.4 | 46.4, 1.2–130.3* | 58.6, 1.4–177.1* | |
| Time control | 15.5, 1.9–171.2 | 17.6, 1.7–156.3 | 21.6, 2.1–160.7 | |
| Urine α1-microglobulin, mg/mmol Cr | NaHCO3 | 3.9, 1.4–10.5 | 5.6, 1.1–11.1 | 5.2, 1.3–11.1 |
| NaCl | 2.8, 1.3–6.1 | 3.6, 1.3–8.0* | 3.4, 1.4–8.1† | |
| Time control | 3.8, 1.0–9.3 | 6.2, 1.5–9.5 | 4.5, 1.0–10.8 |
Statistically significant results are highlighted in bold
Cr creatinine, NaCl sodium chloride, NaHCO3 sodium bicarbonate
*P < 0.05 for the within-group difference versus baseline
†P = 0.06 for the within-group difference versus baseline