Table 3.
Effects of the sodium bicarbonate intervention on exploratory outcomes kidney function, blood pressure, and plasma potassium
| Measurement | Treatment | Baseline | 2 weeks | 4 weeks |
|---|---|---|---|---|
| eGFR, mL/min/1.73m2 | NaHCO3 | 21 ± 6 | 21 ± 5 | 21 ± 5 |
| NaCl | 22 ± 3 | 22 ± 4 | 22 ± 4 | |
| Time control | 20 ± 4 | 20 ± 4 | 20 ± 4 | |
| Creatinine clearance, mL/min | NaHCO3 | 30 ± 10 | 29 ± 11 | 33 ± 12 |
| NaCl | 39 ± 12 | 39 ± 14 | 39 ± 14 | |
| Time control | 32 ± 10 | 33 ± 10 | 30 ± 8 | |
| Creatinine excretion, mmol/day | NaHCO3 | 10.7, 8.7–13.4 | 10.2, 8.0–11.9 | 11.1, 10.3–14.0* |
| NaCl | 13.9, 10.9–17.0 | 12.5, 10.8–18.4 | 12.6, 10.7–16.6 | |
| Time control | 10.3, 8.1–17.7 | 12.9, 7.4–15.2 | 10.7, 8.0–15.1 | |
| Systolic blood pressure, mmHg | NaHCO3 | 134 ± 10 | 132 ± 18 | 132 ± 16 |
| NaCl | 126 ± 12 | 125 ± 13 | 123 ± 13 | |
| Time control | 135 ± 22 | 140 ± 24 | 134 ± 20 | |
| Diastolic blood pressure, mmHg | NaHCO3 | 76 ± 10 | 75 ± 10 | 75 ± 10 |
| NaCl | 78 ± 8 | 77 ± 9 | 78 ± 11 | |
| Time control | 81 ± 12 | 81 ± 10 | 78 ± 12 | |
| Plasma potassium, mmol/l | NaHCO3 | 5.1 ± 0.7 | 4.8 ± 0.5 | 4.8 ± 0.5† |
| NaCl | 5.0 ± 0.6 | 4.9 ± 0.4 | 4.9 ± 0.4 | |
| Time control | 4.9 ± 0.5 | 4.7 ± 0.4* | 4.9 ± 0.5 |
Statistically significant results are highlighted in bold
eGFR estimated glomerular filtration rate, NaCl sodium chloride, NaHCO3 sodium bicarbonate
*P < 0.05 for the within-group difference from baseline
†P = 0.06 for the within-group difference from baseline