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. 2021 Oct 6;12:5848. doi: 10.1038/s41467-021-26153-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Definitions and abbreviations of 15 chromatin states. c Emission probabilities of individual epigenetic marks for each chromatin state. The color from white to deep blue indicates emission probability (0–1). d Genomic coverage of each chromatin state. M ± SD mean ± standard deviation. e Average enrichment of chromatin states for genomic annotations, including CpG islands, genes, TSS/TES_1K (±1 kb around TSS and TES), expressed genes (TPM ≥ 0.1), and repressed genes (TPM < 0.1) in each tissue. f Fold enrichments of chromatin states for non-coding mammalian conserved elements from Genomic Evolutionary Rate Profiling (GERP). Whiskers show 1.5× interquartile range. Each data point represents one of 14 different tissues. g Density of each chromatin state in positions relative to gene TSS. h Average methylation level of chromatin states in jejunum. i Hi-C (250 kb resolution), predicted chromatin states, epigenetic signal, and normalized methylation level in jejunum across chromosome 7. j Chromatin state landscape and mRNA expression at VIL1 locus (chr15:120,459,825-120,493,312, susScr11) across 14 tissues. Vertical scale of UCSC tracks shows normalized signal from 0 to 200 for RNA-seq.