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. 2021 Sep 23;12:757231. doi: 10.3389/fimmu.2021.757231

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Copyright © 2021 Tong, Li, Zhang, Gong, Sun, Calderon, Zhang, Li, Gadzinski, Langdon, Reizis, Zou and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of liver inflammation and fibrosis in CBL^-/-CBL-B^-/- mice is independent of lymphocytes. (A) Body weight comparison between 12-week-old RAG1^-/- and RAG1.CBL tko mice (n = 5). (B) Kaplan-Meier survival analysis of RAG1^-/-, CBL^-/-CBL-B^-/-, and RAG1^-/-CBL tko mice (n = 20). (C) Serum Cytokines IL-6 and TNF-α production in RAG1^-/- and RAG1.CBL tko mice by ELISA (n = 3-4). (D) Serum inflammatory cytokines and chemokines in RAG1.CBL tko mice. (E) Images of skin jaundice (left) and histology analysis of liver fibrosis revealed by H-E staining (right panel) and Masson staining (right panel). Data are mean ± SEM. of at least two independent experiments (C–E). N.S., not significant; *p < 0.05; **p < 0.01; ***p < 0.001.